A mitochondria-derived peptide encoded within the 12S rRNA gene. Research examines its role in AMPK activation, glucose metabolism regulation, and mitochondrial stress response signalling pathways.
Add sterile bacteriostatic water to the vial to achieve your target working concentration.
Storage conditions: -20°C, dry
Form: Lyophilised
Solubility: Water, BAC water
Current batch: MS10-260506-139
HPLC purity: 99.54%
MS verified: Yes
Expiry: May 2028
The certificate of analysis for this batch is issued with your order.
C₁₀₁H₁₅₂N₂₈O₂₂S₂ · 2,174.5 Da
MOTS-c
out of stock
Free shipping on orders over £75
Adults 18+ only. For laboratory research only. Not for use on humans or animals.
Working out volumes? Peptide calculator · Reconstitution guide
MS10-260506-139 · HPLC 99.54%
The batch code matches the vial you will receive. Full analysis — purity, mass spectrometry, residual solvents and microbial limits — is issued with your order.
| Content | 5mg |
| Purity | 99.54% HPLC |
| Form | Lyophilised |
| Storage | -20°C, dry |
| Solubility | Water, BAC water |
Same-day dispatch — order within
Same-day dispatch before 3pm, Mon–Fri. Next dispatch .
via Royal Mail Tracked 24
MOTS-c
5mg · £54.99
MOTS-c is a mitochondria-encoded peptide — one of a small group of peptides transcribed from mitochondrial rather than nuclear DNA. That origin is what distinguishes it and what most of the research interest turns on.
Published work examines its role in metabolic regulation, including a 2022 study in Pharmacological Research on insulin resistance in a gestational diabetes model, and more recent work on cellular signalling published in Advanced Science.
MOTS-c in the UK: sizes, prices and delivery
BSR holds MOTS-c in stock in the UK and posts it by Royal Mail, so an order normally arrives within one or two working days, with no customs charge and no import delay. Each size is one lyophilised vial, for laboratory research use only.
| Size | Price | Per mg | UK stock |
|---|---|---|---|
| MOTS-c 5mg | £54.99 | £11.00 | In stock |
| MOTS-c 10mg | £99.99 | £10.00 | In stock |
| UK delivery | Arrives | Cost |
|---|---|---|
| Royal Mail Tracked 48 | Two working days | £3.95, free on orders over £75 |
| Royal Mail Tracked 24 | Next working day | £4.95 |
| Royal Mail Special Delivery | Guaranteed by 1pm next working day · £750 cover | £10.95 |
Orders placed before 3pm Monday to Friday are dispatched the same working day. Shipping and returns.
Mechanism in the literature
The literature describes MOTS-c as a regulator of metabolic homeostasis, with published models examining effects on insulin sensitivity and glucose handling. Its mitochondrial origin places it in a distinct class from the nuclear-encoded peptides elsewhere in this catalogue.
The evidence base is animal and cell-culture work. MOTS-c has no marketing authorisation and is supplied for laboratory research only.
Handling and reconstitution
Supplied lyophilised at 5mg and 10mg. Standard handling: room temperature, diluent down the wall, gentle swirling.
Storage and stability
Lyophilised at -20°C, protected from light, two-year retest date on the certificate. Reconstituted solution refrigerated, short window, no repeated freeze-thaw.
Common questions
What purity is BSR's MOTS-c?
The current batch tests at 99.54% by HPLC with LC-MS identity confirmation at 2174.3 Da against a theoretical 2174.60. The certificate accompanies your order.
What makes MOTS-c different from other peptides?
It is encoded in mitochondrial DNA rather than nuclear DNA. Most peptides in research use are nuclear-encoded or fully synthetic constructs; MOTS-c belongs to a small group of mitochondrial-derived peptides, and that origin is the focus of much of the published work.
What is MOTS-c used for in laboratory research?
MOTS-c is a mitochondrial-derived peptide, encoded in the 12S rRNA region of mitochondrial DNA rather than the nuclear genome, which is what makes it unusual. The published work is preclinical: cell-culture and mouse studies of metabolic regulation, insulin sensitivity, exercise capacity and ageing, with the folate-methionine cycle and AMPK signalling the mechanisms most often described. It is supplied here as research material for that kind of in-vitro and animal-model work; it holds no marketing authorisation anywhere and is not for human or animal consumption.
How much does MOTS-c cost in the UK?
BSR sells MOTS-c at 5mg £54.99, 10mg £99.99. The 10mg vial works out cheapest at £10.00 per milligram, against £11.00 for the 5mg. UK delivery starts at £3.95, and the cheapest delivery is free on orders over £75.
Where can I buy MOTS-c in the UK?
BSR supplies MOTS-c from stock in the UK at 5mg £54.99, 10mg £99.99, for laboratory research use only. Orders placed before 3pm Monday to Friday are dispatched the same working day by Royal Mail.
How much is MOTS-c 5mg?
MOTS-c 5mg is £54.99 for one 5 mg lyophilised vial, which is £11.00 per milligram. It is in stock in the UK, for laboratory research use only.
How much is MOTS-c 10mg?
MOTS-c 10mg is £99.99 for one 10 mg lyophilised vial, which is £10.00 per milligram. It is in stock in the UK, for laboratory research use only.
- Yin Y. et al. (2022) — MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus, Pharmacological Research
- Yin Y. et al. (2024) — Mitochondrial-Derived Peptide MOTS-c and USP7-Mediated LARS1 Deubiquitination, Advanced Science
Cited as research context. BSR has no involvement in these studies and they do not constitute claims about this product.
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